Yiqun G Shellman Selected Research

ABT-737

7/2017	Use of a MCL-1 inhibitor alone to de-bulk melanoma and in combination to kill melanoma initiating cells.
12/2016	Combining a GSI and BCL-2 inhibitor to overcome melanoma's resistance to current treatments.
3/2015	Combining a BCL2 inhibitor with the retinoid derivative fenretinide targets melanoma cells including melanoma initiating cells.
2/2012	ABT-737 synergizes with Bortezomib to kill melanoma cells.
1/2011	The combination of BH3-mimetic ABT-737 with the alkylating agent temozolomide induces strong synergistic killing of melanoma cells independent of p53.
4/2009	BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis.

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Yiqun G Shellman Research Topics

Disease

26	Melanoma (Melanoma, Malignant) 07/2021 - 09/2002
18	Neoplasms (Cancer) 01/2022 - 09/2002
2	Vitiligo 01/2021 - 01/2018
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/2021
1	Lymphoma (Lymphomas) 08/2020
1	Nevus (Nevi) 01/2020
1	Breast Neoplasms (Breast Cancer) 05/2013
1	Hyperthermia 04/2008
1	Skin Neoplasms (Skin Cancer) 04/2008
1	Edema (Dropsy) 03/2008
1	Inflammation (Inflammations) 03/2008
1	Erythema 03/2008
1	Body Weight (Weight, Body) 03/2008
1	Neoplasm Metastasis (Metastasis) 06/2006
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2005
1	Necrosis 07/2004
1	Hypoxia (Hypoxemia) 10/2003

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 01/2022 - 10/2003
6	ABT-737IBA 07/2017 - 04/2009
4	Pharmaceutical PreparationsIBA 01/2018 - 01/2011
3	Apoptosis Regulatory ProteinsIBA 01/2018 - 02/2012
3	Messenger RNA (mRNA)IBA 01/2018 - 10/2003
2	venetoclaxIBA 07/2021 - 08/2020
2	S63845IBA 08/2020 - 01/2020
2	Immune Checkpoint InhibitorsIBA 08/2020 - 01/2020
2	RNA (Ribonucleic Acid)IBA 07/2020 - 01/2018
2	navitoclaxIBA 01/2020 - 01/2018
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 06/2006
2	MicroRNAs (MicroRNA)IBA 11/2013 - 05/2013
2	Small Interfering RNA (siRNA)IBA 05/2013 - 02/2012
2	Proteasome InhibitorsIBA 02/2012 - 04/2009
2	Caspase 3 (Caspase-3)IBA 04/2008 - 04/2005
1	Azacitidine (5 Azacytidine)FDA Link 07/2021
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2021
1	Myeloid Cell Leukemia Sequence 1 ProteinIBA 08/2020
1	Genetic Markers (Genetic Marker)IBA 01/2020
1	Protein Isoforms (Isoforms)IBA 01/2018
1	Dynamins (Dynamin)IBA 01/2018
1	A-1210477IBA 01/2018
1	entrectinibIBA 01/2018
1	CateninsIBA 01/2018
1	SC-2001IBA 07/2017
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 12/2016
1	RetinoidsIBA 03/2015
1	FenretinideIBA 03/2015
1	Aldehyde DehydrogenaseIBA 03/2015
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 05/2013
1	Carrier Proteins (Binding Protein)IBA 05/2013
1	Bortezomib (Velcade)FDA Link 02/2012
1	Drug CombinationsIBA 02/2012
1	Temozolomide (Temodar)FDA LinkGeneric 01/2011
1	Alkylating AgentsIBA 01/2011
1	benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA 04/2009
1	ras ProteinsIBA 02/2009
1	CaspasesIBA 04/2008
1	DNA (Deoxyribonucleic Acid)IBA 03/2008
1	Microphthalmia-Associated Transcription FactorIBA 03/2008
1	Biological ProductsIBA 03/2008
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2008
1	NucleotidesIBA 03/2008
1	Free RadicalsIBA 03/2008
1	4-O-carboxymethylascochlorinIBA 03/2008
1	bucillamine (SA 96)IBA 03/2008
1	VaccinesIBA 10/2007
1	difluprednate FDA Link 10/2007
1	EpitopesIBA 10/2007
1	Matrix Metalloproteinases (MMPs)IBA 06/2006
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 06/2006
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 06/2006
1	CytokinesIBA 06/2006
1	Interleukin-1beta (Interleukin 1 beta)IBA 06/2006
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2006
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2006
1	Extracellular Matrix ProteinsIBA 06/2006
1	Peptide Hydrolases (Proteases)FDA Link 06/2006
1	Monomeric GTP-Binding ProteinsIBA 04/2006
1	Pravastatin (Pravachol)FDA LinkGeneric 04/2005
1	Annexin A5IBA 04/2005
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 04/2005
1	Lovastatin (Mevacor)FDA LinkGeneric 04/2005
1	Ethidium (Ethidium Bromide)IBA 04/2005
1	CholesterolIBA 04/2005
1	Acridine OrangeIBA 04/2005
1	Laminin (Merosin)IBA 07/2004
1	Fibronectins (Fibronectin)IBA 07/2004
1	IntegrinsIBA 07/2004
1	NucleophosminIBA 10/2003
1	hepatoma-derived growth factorIBA 10/2003
1	GelsIBA 10/2003
1	Angiogenesis Inducing Agents (Angiogenesis Factor)IBA 10/2003
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2003
1	fas Receptor (CD95 Antigen)IBA 09/2002
1	Fas Ligand Protein (Fas Ligand)IBA 09/2002

Therapy/Procedure

7	Therapeutics 07/2021 - 12/2016
4	Immunotherapy 07/2021 - 12/2016
2	Lasers (Laser) 01/2021 - 01/2018
2	Drug Therapy (Chemotherapy) 05/2013 - 01/2011
1	Molecular Targeted Therapy 01/2020
1	Induced Hyperthermia (Thermotherapy) 04/2008